A new Ebola virus disease (EVD) outbreak has been declared in the Democratic Republic of Congo (DRC), prompting a health advisory from the Centers for Disease Control and Prevention (CDC). This outbreak, caused by the Orthoebolavirus zairense species, is centered in the Kasai Province, specifically the Bulape and Mweka health zones.
As of September 18, 2025, the outbreak has resulted in 37 confirmed cases and 19 deaths, including 4 healthcare workers, representing a concerning case fatality rate of 51%. This marks the 16th Ebola outbreak in the DRC since 1976, highlighting the ongoing challenge posed by this deadly virus. The index case involved a 34-year-old pregnant woman who presented with classic EVD symptoms and later succumbed to the disease. Genomic sequencing suggests a novel introduction of the virus from an unknown animal source.
While the risk of spread to the United States remains low due to limited direct flights and access challenges to the outbreak region, the CDC is taking proactive measures. A travel health notice advises against contact with ill individuals in the affected areas and recommends self-monitoring for symptoms for 21 days post-departure. The CDC is also actively supporting the DRC's Ministry of Public Health, providing technical expertise and resources for enhanced surveillance, contact tracing, laboratory testing, and infection prevention.
Ebola virus disease is a severe illness characterized by an incubation period of 2 to 21 days. Initial symptoms, such as fever, aches, and fatigue, are often followed by more severe symptoms including diarrhea, vomiting, and bleeding. Transmission occurs through contact with bodily fluids from infected individuals or animals, or via contaminated objects. Airborne transmission is not a concern. An FDA-approved vaccine, ERVEBO®, and treatments like Inmazeb™ and Ebanga™ are available but require specific criteria for administration.
The CDC emphasizes the importance of early diagnosis and treatment for improved outcomes. Healthcare providers are urged to consider EVD in their differential diagnosis for patients presenting with relevant symptoms and a recent travel history to the affected region. The CDC is actively working with healthcare providers, public health departments, and organizations to raise awareness and ensure a coordinated response to this significant public health threat. Further information and resources are available on the CDC website.
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Originally published at: https://www.cdc.gov/han/php/notices/han00524.html
