Maria Branyas, a Spanish woman who passed away at the remarkable age of 117, has offered scientists a unique opportunity to delve into the complexities of human longevity. Her exceptional lifespan prompted a comprehensive study published in Cell Reports Medicine, exploring the interplay of genetics and lifestyle in achieving such an extended life. Researchers meticulously analyzed samples of her blood, saliva, urine, and stool, examining her genetic makeup and microbiome. While she exhibited typical biomarkers of advanced age, including shortened telomeres and age-related B-cell accumulation, surprising findings emerged.
Despite these indicators, Branyas displayed surprisingly low inflammation levels and a surprisingly youthful epigenome – modifications in gene expression without altering the underlying DNA sequence. Furthermore, her genome revealed unusual variations that appeared to offer protection against common age-related diseases such as heart disease, diabetes, and neurodegenerative conditions like Alzheimer's and Parkinson's. This suggests a possible decoupling of ageing and disease progression, challenging the conventional understanding that they are inextricably linked.
Beyond her genetics, Branyas' lifestyle also played a significant role. Her diet primarily consisted of a Mediterranean-style approach, with a notable daily intake of three yoghurts, which researchers believe contributed to her healthy gut and weight management. Maintaining good sleep hygiene, physical activity, and positive mental well-being were also integral parts of her daily routine. A vibrant social life, enriched by hobbies such as reading, playing the piano, and gardening, contributed to a well-rounded and fulfilling existence.
The study's findings offer valuable insights into healthy ageing and potential strategies for increasing life expectancy. While genetic predispositions certainly play a crucial role, the study highlights the significant influence of lifestyle choices in supporting longevity. Branyas' case provides a compelling example of how a combination of genetic advantages and healthy lifestyle habits can contribute to an exceptionally long and healthy life. Further research is warranted to fully elucidate the mechanisms underlying these findings and to translate them into practical recommendations for promoting healthy aging in the broader population.
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Originally published at: https://www.euronews.com/health/2025/09/25/this-spanish-woman-lived-to-117-scientists-may-have-discovered-why
